What effect does the metabolite DDE have on male alligators?

The metabolite DDE, which is a breakdown product of the pesticide DDT, is known to have endocrine-disrupting effects, particularly in wildlife. In male alligators, exposure to DDE has been associated with reduced activity of the testosterone receptor. This occurs because DDE can bind to hormonal receptors and interfere with their normal functioning, leading to a condition known as receptor antagonism.

As a result, when testosterone is present, its ability to exert biological effects through the receptor is diminished, impacting male reproductive health. This can manifest in various physiological changes, including abnormalities in reproductive organs and overall fertility issues. Understanding this mechanism is crucial for assessing the ecological impact of chemical pollutants and the health of alligator populations in affected areas.